Spravato® Treatment in the Twin Cities

FDA-Approved Relief for Treatment-Resistant Depression

What Is Spravato?

Spravato® (esketamine) is a prescription nasal spray approved by the FDA for adults with treatment-resistant depression (TRD) and depression with suicidal thoughts.
It’s a form of ketamine that works differently from traditional antidepressants. Spravato® is the first and only rapid-acting depression medication approved by the FDA.

At Modern Experience Clinic, Spravato is administered in a calm, medically supervised setting by a physician-led team. We are a certified Spravato REMS clinic in Maple Grove, MN.

Who Is Spravato For?

Spravato may be right for you if:

  • You’ve tried 2 or more antidepressants without success

  • You struggle with ongoing depressive symptoms despite treatment

  • You’ve experienced suicidal thoughts associated with depression

Why Choose Spravato at The ME Clinic?

  • ✅ Administered by physicians in a private, calming environment

  • ✅ Insurance often covers most or all of the cost

  • ✅ Certified Spravato REMS site

  • ✅ We handle all prior authorizations and insurance coordination

  • ✅ Personalized support throughout the process

How Does Spravato Work?

Spravato targets the glutamate system, rapidly activating new brain pathways and reducing inflammation.
Unlike SSRIs or SNRIs that take weeks to work, Spravato may begin improving mood within hours to days.

It’s used alongside an oral antidepressant as part of a complete treatment plan.

What to Expect During Treatment

  1. Insurance & Safety Screening
    We verify your benefits and medical history before starting.

  2. Initial Dosing
    Spravato is self-administered via nasal spray under supervision in our clinic.

  3. Observation Period
    You’ll relax in a private room for ~2 hours post-treatment while our staff monitors your vitals and comfort.

  4. Follow-Up Care
    You’ll continue twice-weekly, then weekly sessions based on your response and insurance plan.

Common Side Effects

  • Dizziness or dissociation

  • Fatigue

  • Nausea

  • Increased blood pressure (temporary)

Most side effects resolve within the observation window. You cannot drive home the day of treatment.

Insurance Coverage for Spravato

Spravato is widely covered by Minnesota health plans including:

  • Blue Cross Blue Shield of MN

  • UCare

  • HealthPartners

  • Medica

  • Aetna, Cigna, and others

We manage all paperwork and prior authorizations, so you can focus on healing.

FAQs

How is Spravato different from ketamine infusions?
Spravato is a nasal spray form of esketamine, FDA-approved and typically covered by insurance. Infusions are IV-based and offer more dosing flexibility but are often out-of-pocket.

Can I drive after treatment?
No. You’ll need a ride home after every session.

Is it safe long term?
Yes. Spravato has been studied extensively in long-term use and is considered safe under medical supervision.

How long does it take to work?
Some patients feel better after the first session. Most experience improvements within 2–4 weeks.

Take the Next Step Toward Relief

If nothing else has worked, Spravato may be the breakthrough you’ve been waiting for.
We’ll help you navigate every step from insurance to treatment to recovery.